Assessing Efficacy of Intravenous Acetaminophen for Perioperative Pain Treatment in Spinal Surgery

• Status: Completed
• Trial end date: 2023-02-03
• Target enrollment: 0
• Participant gender: All

Summary

Spinal surgeries are generally associated with intense pain in the postoperative period, especially for the initial few days. The aim of this study is to examine the effect of intraoperative intravenous acetaminophen in spine surgery on postoperative analgesic requirements, pain scores, patient satisfaction, and clinical recovery. Enrolled patients are randomized to receive either intravenous acetaminophen or placebo at the time of surgical closure. It is hypothesized that patients receiving intravenous acetaminophen will have improved pain scores, require less opiate medication, and have better patient satisfaction than those receiving placebo.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Massachusetts General Hospital
• Treatments: Acetaminophen

Criteria

Inclusion Criteria:

• Patients undergoing 1-2 levels primary spine surgery ≥18 years old

Exclusion Criteria:

• Chronic opiate users

• More than 3 levels or revision spine surgery

• Liver disease patients include elevated LFT, hepatitis A, hepatitis B or hepatitis C, cirrhosis, fatty liver disease, and any other liver diseases caused by drugs, poisons, or alcohol(s)

• Allergy/hypersensitivity to acetaminophen

• Patients that have used acetaminophen during the 24 hours before their scheduled surgery