Assessing Response to Treatment in Non-Hodgkin's Lymphoma Patients Using 64Cu-DOTA-Rituximab PET/CT

• Status: Withdrawn
• Trial end date: 2015-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Rituximab is an antibody targeted against the CD20 antigen found primarily on B-cells. Therefore, an imaging agent targeting CD20 expression may provide a more accurate evaluation of extent of disease and response to therapy than the current standard of care, F-18 FDG PET/CT.

The main purpose of the study is to investigate a new PET/CT imaging probe for detection and follow up of lymphoma. Following are the 3 aims of the study: a) Phase I testing in lymphoma patients of Cu-64 labelled Rituxan for defining normal tracer biodistribution, stability, pharmacokinetics and radiation dosimetry; b) comparison of Cu-64 Rituxan and F-18 FDG PET/CT in lymphoma patients; c) evaluation of changes in uptake of Cu-64 Rituxan in response to rituximab-based treatment in CD20-positive B-cell NHL

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sanjiv Sam Gambhir
• Treatments: Rituximab

Criteria

Inclusion Criteria:

• Patients must have a diagnosis of CD20-positive B-cell NHL and a staging 18F FDG PET/CT prior to the 64Cu-DOTA-Rituximab PET/CT

• Patients must understand and voluntarily sign an Informed Consent form after the contents have been fully explained to them

• Patients must be scheduled for rituximab-based therapy

• Patients must be older than 18-year-old

Exclusion Criteria:

• Patients who cannot complete a PET/CT scan

• Pregnant women

• Patients participating in other research protocols will be excluded from this study