Assessing Response to Treatment in Non-Hodgkin's Lymphoma Patients Using 64Cu-DOTA-Rituximab PET/CT
Status:
Withdrawn
Trial end date:
2015-12-01
Target enrollment:
Participant gender:
Summary
Rituximab is an antibody targeted against the CD20 antigen found primarily on B-cells.
Therefore, an imaging agent targeting CD20 expression may provide a more accurate evaluation
of extent of disease and response to therapy than the current standard of care, F-18 FDG
PET/CT.
The main purpose of the study is to investigate a new PET/CT imaging probe for detection and
follow up of lymphoma. Following are the 3 aims of the study: a) Phase I testing in lymphoma
patients of Cu-64 labelled Rituxan for defining normal tracer biodistribution, stability,
pharmacokinetics and radiation dosimetry; b) comparison of Cu-64 Rituxan and F-18 FDG PET/CT
in lymphoma patients; c) evaluation of changes in uptake of Cu-64 Rituxan in response to
rituximab-based treatment in CD20-positive B-cell NHL