Assessment of Cholinergic and Cognitive Function Using Pharmacologic ASL-Perfusion MRI

• Status: Completed
• Trial end date: 2013-01-01
• Target enrollment: 0
• Participant gender: All

Summary

This research study will look at how medications affect the pattern of blood flow in the brain. This study will use a special type of MRI (magnetic resonance imaging) scan called perfusion MRI to make measurements of cerebral (brain) blood flow. The medications we will use in this study are scopolamine (commonly used to treat motion sickness), mecamylamine (used to treat high blood pressure), and donepezil (used to treat memory loss). Cognitive testing will also be obtained, and correlated with the blood flow patterns in the brain.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Hebrew Rehabilitation Center, Boston; Hebrew SeniorLife
• Treatments: Butylscopolammonium Bromide; Cholinergic Agents; Donepezil; Scopolamine; Scopolamine Hydrobromide

Criteria

Inclusion Criteria:

• healthy volunteers

Exclusion Criteria:

• Any neurological condition, such as brain tumor, history of stroke, seizure disorder, attention deficit disorder, normal pressure hydrocephalus, dementia, traumatic brain injury

• Any major medical conditions, such a cancer, diabetes, glaucoma, prostate disease, uncontrolled hypertension

• antihistamine use

• tricyclic antidepressant use

• presence of metal in body, including pacemaker, defibrillator, neurostimulator, metal implants, or foreign metal objects such as bullets or shrapnel.

• anxiety or panic disorder

• history of claustrophobia

• pregnancy