Assessment of Endothelial Function in Patients With Non Alcoholic Fatty Liver Disease and the Impact of Statin Treatment

• Status: Withdrawn
• Trial end date: 2015-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the current study is to evaluate the association of fatty liver severity and endothelial function in Non-Alcoholic Fatty Liver Disease (NAFLD) patients and to find the impact of statin treatment compared to usual care or life style modification on endothelial function, liver steatosis and fibrosis.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sheba Medical Center
• Treatments: Atorvastatin; Atorvastatin Calcium; Hydroxymethylglutaryl-CoA Reductase Inhibitors

Criteria

Inclusion Criteria:

• subjects willing to comply with study requirements and have signed an informed consent form

• fatty liver per abdominal ultrasound or liver biopsy

Exclusion Criteria:

• alcohol drinking >140g/week

• presence of hepatitis B or C or HIV

• known liver disease other than fatty liver

• usage of drugs known to cause liver steatosis

• subjects with known allergies or hypersensitivity to statins

• subjects with known cardiovascular/cerebrovascular disease

• subjects with known dyslipidemia requiring drug treatment

• subjects with diabetes mellitus

• history of drug or alcohol abuse

• refusal to sig the informed consent form