Assessment of Mechanisms of Improved Wound Healing

• Status: Completed
• Trial end date: 2013-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to find ways to improve wound healing and decrease the negative effects of trauma from burn injury.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The University of Texas Medical Branch, Galveston
• Collaborators: National Institute of General Medical Sciences (NIGMS); National Institutes of Health (NIH)
• Treatments: Clonidine; Dehydroepiandrosterone; Exenatide; Fenofibrate; Fluconazole; Hormones; Hydroxyitraconazole; Insulin; Insulin, Globin Zinc; Itraconazole; Ketoconazole; Metformin; Methyltestosterone; Nandrolone; Oxandrolone; Pioglitazone; Propranolol; Testosterone; Testosterone 17 beta-cypionate; Testosterone enanthate; Testosterone undecanoate

Criteria

Inclusion Criteria:

• Patient is between 0 and 90 years of age

• Patient 18 years and older consents to participate in study protocol. If patient is not able to consent, consent will be obtained from closest family member or legal guardian. Parental permission will be obtained for patients less than 18 years of age. Assent will be obtained from children 7-17 years of age if child is physically/mentally able to do so.

• greater than 30% TBSA burn requiring at least 1 operation with donor sites for skin grafting

Exclusion Criteria:

• Known history of AIDS, AIDS-related complex, Human Immunodeficiency Virus

• History of cancer within 5 years

• Tuberculosis, arthritis, cirrhosis, hyperlipidemia, bone or endocrine diseases, autoimmune diseases

• Chronic glucocorticoid or non-steroidal anti-inflammatory drug therapy