Assessment of Metabolic Response in Critically Ill Patients With Acute Renal Failure

• Status: Terminated
• Trial end date: 2005-07-01
• Target enrollment: 0
• Participant gender: All

Summary

We hypothesize that a nutritional supplementation with higher than standard protein content (2.0 gm/Kg/day vs 1.4 gm/Kg/day) will result in improved whole-body net protein balance when administered to critically ill patients with acute renal failure (ARF).

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Vanderbilt University; Vanderbilt University Medical Center

Criteria

Inclusion Criteria:

• Adults ≥ 18 years of age admitted to the intensive care unit

• New onset acute renal failure (ARF) or ARF superimposed on chronic kidney disease

• ARF will be defined by a sustained (over 24 hours) increase in serum creatinine > 0.5 mg/dl from baseline

• Patients will be recruited for the study within 3-5 days following establishment of ARF

Exclusion Criteria:

• Institutionalized patient

• Previous kidney transplant

• Pregnancy

• Unable to obtain consent from subject or legally recognized representative

• ARF from urinary tract obstruction or a volume responsive pre-renal state.

• Liver Failure

• Recent cerebrovascular accident (CVA)

• Coagulopathy defined as: Platelets < 50, PT > 20, INR > 2.0 if the patient requires the placement of an arterial or venous catheter; if the patient does not require the placement of an arterial or venous catheter for the study, coagulopathy will not be a basis for exclusion.

• Life expectancy < 48 hours