Assessment of Oxygen Changes in the Heart With Cardio-vascular Magnetic Resonance Imaging

• Status: Completed
• Trial end date: 2011-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The ability of a new SSFP-based BOLD MRI sequence to assess myocardial oxygenation changes in response to coronary flow changes induced by adenosine and increased CO2-partial pressure will be examined in healthy volunteers and patients with suspected coronary artery disease. Also the susceptibility of a new SSFP-based BOLD sensitive MRI sequence to changes in arterial oxygenation will be examined. This will help understand the physiologic basis of oxygen sensitive imaging of the heart.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Calgary
• Treatments: Adenosine

Criteria

Inclusion Criteria:

• Informed written consent

• age > 18 years

• no known cardiovascular disease and no vasoactive medication (if recruited as healthy volunteer)

• suspected coronary artery disease or microvascular dysfunction (if recruited as patient)

• no known obstructive or restrictive lung disease

• fasting for 4 hours prior to the study

Exclusion Criteria:

• Contraindications for MRI

• Known obstructive or restrictive lung disease

• concomitant serious medical condition