Assessment of Probiotics Lactobacillus in the Management of Attention Deficit Hyperactive Disorder
Status:
Unknown status
Trial end date:
2020-12-30
Target enrollment:
Participant gender:
Summary
ADHD is a neurodevelopmental disorder characterized by persistent symptoms of inattention
and/or hyperactivity and impulsivity that are present before age 18. These symptoms must be
evident across ADHD treatment is currently based on a multimodal approach with the
combination of psychotherapy and pharmacotherapy, but no reliable markers of treatment
response have been identified yet and 20-35% of subjects in clinical trials may have an
inadequate response to the treatment The gut microbiome refers to the microbial ecosystem
found in the gastrointestinal system of the human species Probiotics are a type of beneficial
bacteria that improve health and facilitate intestinal microbial balance Increasing evidence
suggests that the gut microbiota plays a key role in the gut-brain communication axis by
influencing metabolism, inflammation, the hypothalamic-pituitary-adrenal axis, and
neurotransmission multiple domains and cause Impairment in functioning in order to meet the
diagnostic criteria for ADHD