Assessment of Reactance Parameters Measured by the Forced Oscillation Technique for the Bronchodilator Response in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

• Status: Not yet recruiting
• Trial end date: 2021-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The aims of this study is :

• to assess the bronchodilator (DUOVENT HFA) response of parameters measured by the forced oscillations (FOT) and in particular the reactance parameters related to the presence of a limitation of expiratory flows

• to compare the response of the reactance parameters to bronchodilators with the conventional spirometric parameters (FEV1) and inspiratory capacity (IC), and according to the severity of the disease

• to assess and compare the relationship between the response to bronchodilators in terms of IC on the one hand and on the other hand in terms of FEV1, reactance parameters (measured by FOT), resistance parameters (measured by plethysmography and FOT)

• Assess and compare the relationship between dyspnea intensity assessed by various scales and conventional respiratory function parameters (spirometry, plethysmography, diffusion indices) and parameters measured by FOT

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Centre Hospitalier Universitaire Dinant Godinne - UCL Namur
• Treatments: Bronchodilator Agents; Fenoterol, ipratropium drug combination

Criteria

Inclusion Criteria:

• Clinical diagnosis of COPD confirmed by post-bronchodilator (DUOVENT HFA 4 puffs) obstructive airway obstruction (FEV1/Forced Vital Capacity < Percentile 5) persisting after bronchodilatation

• Former or active smoking > 10 packs/year

• Age > 40 years

• Informed consent

Exclusion Criteria:

• Inability to comply with bronchodilator weaning time :

6 hours for short-acting bronchodilators ; 12 hours for long-acting bronchodilators ; 24 hours for very long-acting bronchodilators

• Inability to comply with the 4 hours of smoking cessation before the measurements

• Inability to perform respiratory function tests

• Continuous oxygen therapy

• Close angle glaucoma

• History of urinary retention (only for patients not usually treated with anticholinergic bronchodilators)

• Pregnancy

• Acute illness contraindicating the performance of respiratory tests