Assessment of Sensitivity of the Hypothalamic GnRH Pulse Generator to Estradiol and Progesterone Inhibition
Status:
Terminated
Trial end date:
2013-05-14
Target enrollment:
Participant gender:
Summary
Gonadotropin-releasing hormone (GnRH) is a hormone that regulates the ability of the
pituitary to secrete two hormones, luteinizing hormone (LH) and follicle-stimulating hormone
(FSH). LH and FSH control the production of female hormones (such as estrogen and
progesterone) and the development of eggs by the ovary. Progesterone and estrogen then
decrease the number of GnRH pulses produced by the brain (and therefore the number of LH
pulses from the pituitary). The ability to decrease GnRH pulses seems to be very important
for normal menstrual function in adult women. The purpose of this study is to learn more
about how GnRH and LH pulses are controlled during puberty. The information gathered in this
study will hopefully allow us to learn more about how menstrual cycles are normally
established in girls during puberty.
Phase:
N/A
Details
Lead Sponsor:
University of Virginia
Collaborator:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)