Assessment of Target Site Pharmacokinetics of Voriconazole in Healthy Volunteers During Sequence Therapy
Status:
Completed
Trial end date:
2013-08-01
Target enrollment:
Participant gender:
Summary
The present study aims at measuring unbound voriconazole concentrations in plasma and at the
relevant target site of systemic fungal infections, i.e. the interstitial space fluid of soft
tissues, to assess the target site pharmacokinetics. For this purpose the microdialysis
technique will be employed which is capable of measuring the unbound, microbiologically
active concentration of antifungals in the interstitial space fluid of virtually all tissues.
This is the first human study of this drug employing the microdialysis technique determining
the target site concentrations over several days (single and multiple dosing).