Assessment of Use of Rapid Diagnostic Testing in the Context of Home Management With ACTs
Status:
Completed
Trial end date:
2012-01-01
Target enrollment:
Participant gender:
Summary
This study is to assess the value of incorporating a malaria RDT based strategy in HMM. The
primary activity of the study wil be a two armed cluster randomised trial in two study sites
in Uganda, one in Ghana and one in Burkina Faso. One of the Uganda sites is highly endemic
and the other meso-endemic for malaria. In one arm the children will be treated presumptively
for malaria with ACT (control arm) and the other arm the children will receive ACT only when
they have a positive RDT result (implementation arm). The children in the implementation arm
will also receive antibiotics if they have a raised respiratory rate. The primary outcome
will be the recovery rate in the intervention arm compared to that of the control arm on Day
3. In addition, an acceptability assessment of RDTs in the community will be undertaken both
before and after the intervention trial and a cost-effectiveness analysis of the RDT strategy
will also be completed. For a sub-sample, microscopy slides will also be taken on Day 0 to
demonstrate comparable levels of endemicity in control and intervention groups. These
activities will be carried out over a two year period.
Phase:
N/A
Details
Lead Sponsor:
Mbarara University of Science and Technology
Collaborators:
Makerere University Ministry of Health, Uganda National Malaria Research and Training Centre, Burkina Faso Navrongo Health Research Centre, Ghana