Assessment of the Changes in Cortical and Medullary Renal Blood Flow During Exercise in Healthy Subjects Using Contrast Enhanced Ultrasound

• Status: Unknown status
• Trial end date: 2017-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Renal parenchymal blood flow can be divided in cortical and medullary blood flow. Changes and factors affecting renal medullary blood flow have not been studied in detail previously as investigators/doctors did not have tools to monitor renal medullary blood flow in vivo. Since Trueta first described renal medullary blood flow, multiple attempts have been made to study renal medullary blood flow using invasive methods. Recently renal medullary blood flow measurement using contrast US has emerged as a promising technique that investigators can use to study renal medullary blood flow in vivo. In this study investigators are aiming to study changes in renal parenchymal (cortical and medullary) blood flow with exercise in healthy subject.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Virginia

Criteria

Inclusion Criteria:

• Healthy Adult - 18 to 50 years old

• All ethnicity and genders

Exclusion Criteria:

• Pregnancy or lactation

• Active infection

• Hypertension

• Chronic Medication Use except Multi Vitamin Use and Birth Control Medications

• Known history of a right to left intra-cardiac shunt

• Known history of pulmonary hypertension, including porto-pulmonary hypertension

• History of allergies to Definity®

• History of Liver or Kidney Transplant

• Patient on hemodialysis

• Has received iodinated contrast within 72 hours of admission to study