Assessment of the Pharmacodynamic Effect on Plasma Folate and Red Blood Cell Folate and Comparison of the Folate Metabolites During the 24 Weeks of Treatment (Yasmin + Metafolin Versus Yasmin + Folic Acid) Followed by a 20 Week Elimination Phase of

• Status: Completed
• Trial end date: 2008-01-01

Summary

The purpose of this study is to examine and compare the uptake of levomefolate calcium (Metafolin, a registered vitamin supplement) and folic acid in the body during 24 weeks of treatment with a following folate elimination phase of 20 weeks in healthy volunteers seeking contraception. Yasmin (oral contraceptive containing drospirenone and ethinylestradiol) was co-administered over the entire period of 44 weeks.

• Phase: Phase 1

Details

• Lead Sponsor: Bayer
• Treatments: Drospirenone; Drospirenone and ethinyl estradiol combination; Ethinyl Estradiol; Folic Acid; Hormones; Vitamin B Complex