Association Between CytochromeP4501A2 and CytochromeP4502E1 Gene Polymorphisms and Metabolism of Theophylline

• Status: Completed
• Trial end date: 2014-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to determine whether common CYP1A2 and CYP2E1 gene polymorphisms effect metabolism of theophylline in chronic obstructive pulmonary disease patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Zhujiang Hospital
• Treatments: Theophylline

Criteria

Inclusion Criteria:

• Aged 18-75 years,COPD patients, male or female;

• regularly visiting our hospital;

• taking a sustained-release preparation of theophylline continuously for at least 2 weeks

Exclusion Criteria:

• patients with renal or hepatic dysfunction;

• patients with congestive heart failure;

• patients with hypothyroidism or hyperthyroidism;

• patients currently taking drugs likely to affect theophylline metabolism or who had taken such drugs in the preceding week;

• patients with extreme obesity

• patients with very severe Chronic Obstructive Pulmonary Disease(COPD)