Association of Functional COMT Val108/Met Polymorphism With Smoking Cessation in Nicotine Replacement Therapy
Status:
Completed
Trial end date:
2004-12-01
Target enrollment:
Participant gender:
Summary
Nicotine replacement treatment (NRT) can be efficacious for smoking cessation, but used by
only a minority of smokers in China. Pharmacogenetic matching may improve treatment outcomes
for NRT in subgroups of smokers. The investigators evaluated the efficacy and safety of
sublingual nicotine tablets (SNT) for smoking cessation and the association of
catechol-O-methyltransferase (COMT) genotype with efficacy in this smoking cessation trial
among Chinese smokers.