Associations Between the Oral and Intestinal Icrobiome and Neovascular Age-related Macular Degeneration

• Status: Recruiting
• Trial end date: 2024-12-31
• Target enrollment: 0
• Participant gender: All

Summary

A pilot study for Associations between the oral and intestinal microbiome and neovascular age-related macular degeneration and the investigation on the effect of oral probiotics as a treatment

The investigators recruit the neovascular AMD patients and control patients.

1. 15 neovascular AMD patients with anti-VEGF treatment and oral probiotics supplement

2. 15 neovascular AMD patients with anti-VEGF treatment and no oral probiotics supplement

3. 15 control patients and no oral probiotics supplement

The investigators will collect stool, blood, and saliva sample at the baseline and 6 months, and analyze the oral and intestinal microbiome changes.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Seoul National University Bundang Hospital

Criteria

Inclusion Criteria:

• Normal BMI patients

• Diagnosed as neovascular AMD (experimental & sham group)

• Normal patients (control group)

Exclusion Criteria:

• Obese (BMI > 25)

• Past surgical history involving intestinal diseases

• Previous oral antibiotic treatment before 1 week at the baseline enroll

• Previous oral probiotics supplement

• Previous ophthalmic retinal diseases except neovascular AMD