Asymptomatic Bacteriuria & Risk of Urinary Tract Infection in Renal Transplants

• Status: Unknown status
• Trial end date: 2013-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this research program is to understand the natural history of asymptomatic bacteriuria in the renal transplant patients, to determine if screening for asymptomatic bacteriuria and identification of key host characteristics and virulence factors present on uropathogenic bacteria identifies a sub-population of patients with asymptomatic bacteriuria that are at risk to develop symptomatic urinary tract infection. Ultimately, the knowledge obtained from this study will prevent inappropriate antibiotic use and may identify whether certain bacterial isolates predispose to renal allograft injury. We will test the hypothesis that (i) asymptomatic bacteriuria is common in the renal allograft recipient and (ii) that symptomatic urinary tract infection and renal allograft dysfunction do not occur unless key host susceptibility factors and uropathogenic bacterial virulence factors are present.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rice, James C., M.D.
• Collaborator: University of Alabama at Birmingham
• Treatments: Ampicillin; Anti-Bacterial Agents; Antibiotics, Antitubercular; Cefazolin; Ciprofloxacin; Gentamicins; Levofloxacin; Nitrofurantoin; Ofloxacin; Sulbactam; Sulfamethoxazole; Tobramycin; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

Criteria

Inclusion Criteria:

• must be 18 years old or older,

• had a kidney transplant,

• be at least 30 days post operation.

Exclusion Criteria:

• Pregnant women, those planning to become pregnant or nursing mothers;

• Renal transplant patients less than 30 days post transplant; Use of an indwelling Foley catheter;

• Patients without a renal transplant;

• Patients having concurrent surgical/wound infection and presumed hematogenous dissemination for the urinary tract.