Atorvastatin Plus Ezetimibe on Coronary Plaque Progression
Status:
Unknown status
Trial end date:
2012-12-01
Target enrollment:
Participant gender:
Summary
Atherosclerosis is a progressive disease. Lipid lowering therapy was the standard treatment
for patients with coronary artery disease. Studies indicated that coronary artery plaque
progression had positive relationship with the plasma cholesterol level, and could be halted
or reversed by intensive statin therapy (such as 20-40 mg/d atorvastatin). Ezetimibe plus
statin could further lowered blood cholesterol level. Here the investigators hypothesize that
same cholesterol lowering level by routing dose of atorvastatin or lower dose of atorvastatin
plus ezetimibe could achieve the same effect on coronary artery plaque cessation or
regression.