Atorvastatin for Reduction of Myocardial Damage During Angiography and Its Mechanism Associated With IMR

• Status: Unknown status
• Trial end date: 2014-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether preoperative loading dose atorvastatin can prevent perioperative myocardial infarction during angiography and main adverse cardiac events 1 month after operation in stable angina, unstable angina and acute non-ST-segment elevation myocardial infarction patients undergoing elective coronary angiography and PCI, and determine whether its mechanisms are associated with microcirculation resistance.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Central South University
• Treatments: Atorvastatin; Atorvastatin Calcium

Criteria

Inclusion Criteria:

• Patients with stable angina

• Patients with unstable angina patients

• Patients with acute non STsegment elevation myocardial infarction

• Patients willing to accept the need regular follow-up of this study

• Patients 18-75 years of age

• Patients who signed an informed consent form

Exclusion Criteria:

• ST segment elevation acute myocardial infarction

• Emergency coronary angiography in patients

• Patients with abnormal liver function

• Heavily calcified, distortions coronary lesions

• LVEF <30% of patients

• eGFR<30ml/min/1.73 Square meters

• Liver disease or a history of muscle disease