Atorvastatin in Preventing Nasopharyngeal Carcinoma Patients Receiving Radiotherapy From Carotid Stenosis
Status:
Suspended
Trial end date:
2024-01-01
Target enrollment:
Participant gender:
Summary
Patients with head and neck cancer who underwent irradiation have a higher risk of developing
severe carotid stenosis, and eventually develop to transient ischemic attack or stroke.
However, it's still not clear whether early intervene in vascular risk factors is benefit for
patients after radiotherapy.
Our study aimed to evaluate the feasibility and safety of atorvastatin for preventing NPC
patients after radiotherapy from severe carotid stenosis. In a randomized, double-blind,
placebo-controlled trial, about 324 nasopharyngeal carcinoma (NPC) patients will be enrolled
from six centers in Guangdong Province and randomized 1:1 to atorvastatin group or placebo
group.
Phase:
Phase 2
Details
Lead Sponsor:
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University