Atorvastatin to Prevent Avascular Necrosis of Bone in Steroid Treated Exacerbated Systemic Lupus Erythematosus
Status:
Terminated
Trial end date:
2008-01-01
Target enrollment:
Participant gender:
Summary
This study uses the cholesterol lowering drug atorvastatin, also known as lipitor, to show
reduction of avascular necrosis in steroid treated lupus patients. Avascular necrosis is a
disease resulting from the loss of blood supply to the bones which can cause the bone to
collapse. The collapse of bone may require a surgical replacement of the joint and can be
disabling for life. Avascular necrosis is presently not preventable but research has shown
that lipid lowering drugs such as lipitor can reduce or prevent avascular necrosis in
animals. We therefore hypothesize that lipitor will reduce the incidence of avascular
necrosis in lupus patients taking high dose steroids.
Phase:
Phase 2
Details
Lead Sponsor:
New York University School of Medicine NYU Langone Health