Atropin and Glucose Stimulated Insulinsecretion and the Cephalic Insulin Response

• Status: Unknown status
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: Male

Summary

The aim of this study is to investigate the role of transmission of vagal cholinerg for the GLP-1 potentiation of the glucose stimulated insulin secretion and the cephalic insulin response by using atropin administration.

The hypothesis is that a great deal of the effects of GLP-1 is mediated via the nervous system and for this reason the investigators will research individuals with an intact nervous supply with and without atropin administration.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital, Gentofte, Copenhagen
• Collaborator: University of Copenhagen
• Treatments: Atropine; Insulin

Criteria

Inclusion Criteria:

• age between 18 and 45 years

• normal fasting plasma glucose

• normal hemoglobin

• informed consent

Exclusion Criteria:

• diabetes mellitus

• body mass index above 30

• inflamatoric bowel disease

• intestinal surgery

• serum creatinine above 250 microM

• ALAT above to times normal value

• treatment with medicine wich cannot be paused for 12 hours

• contraindication for treatment with atropin