Atropine-effect During Propofol/Remifentanil Induction
Status:
Completed
Trial end date:
2013-06-01
Target enrollment:
Participant gender:
Summary
Remifentanil is a widely used potent intravenous opioid with the advantage of having a short
time of action. Compared to other opiates however remifentanil generates more intense
hemodynamic side-effects. In ophthalmic surgery the specific anesthesiological challenges
necessitate the administration of a combination of relatively high doses of analgesics on the
one hand and a short time for postoperative recovery from anesthesia on the other. For these
reasons, anesthetic management often consists of a combination of relatively high doses of
propofol and remifentanil. A primary concern during this deep propofol/remifentanil
anesthesia is preserving hemodynamic stability and adequate tissue oxygenation. Previous
research of the investigators group has revealed that atropine has an exceptionally
beneficial effect on hemodynamics as well as on tissue oxygenation. Therefore, the
investigators hypothesize that administration of intravenous atropine during induction of
propofol/remifentanil may have a positive effect on the hemodynamic profile and peripheral
and cerebral tissue oxygenation during and after induction of anesthesia.