Attenuating The Post-Operative Insulin Resistance And Promoting Protein Anabolism
Status:
Terminated
Trial end date:
2018-03-01
Target enrollment:
Participant gender:
Summary
Major surgery results in a stress- induced catabolic response, marked by post-operative
insulin resistance, hyperglycemia and loss of body protein, which is associated with
increased morbidity, mortality and adverse outcomes. There has been a great deal of research
on different approaches to optimize post-operative insulin sensitivity including hormonal and
nutritional interventions, minimally invasive surgical techniques and epidural anesthesia.
However, the correlation between insulin resistance and body protein loss is not well
understood. Metformin is the most widely used insulin sensitizing and blood glucose-lowering
drug in treatment of type 2 diabetic patients. This study will: 1) estimate the correlation
between insulin resistance and body protein loss in pre-diabetic lung/colorectal resection
patients; 2) investigate whether the post-operative metabolic state can be improved by the
pre-operative administration of metformin; and assess the impact of metformin on surgical
complications and hospital length of stay. The results of this study will provide insight
into the relationship between insulin resistance and post-operative adverse events and
potentially suggest a novel approach to improve outcomes using Metformin, a drug already in
wide clinical use.
Phase:
N/A
Details
Lead Sponsor:
McGill University Health Center McGill University Health Centre/Research Institute of the McGill University Health Centre