Attenuation of Airway and Cardiovascular Responses to Extubation in Chronic Smokers

• Status: Recruiting
• Trial end date: 2021-03-20
• Target enrollment: 0
• Participant gender: Male

Summary

The aim of this blind comparative study was to compare the effects of dexmedetomidine, fentanyl and their combination on airway reflexes and hemodynamic responses to tracheal extubation in Adult chronic male smoking patients scheduled for abdominal surgeries (of average 2-3 hours duration).

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Cancer Institute, Egypt
• Treatments: Dexmedetomidine; Fentanyl

Criteria

Inclusion Criteria:

• Chronic cigarette smokers (patients have smoked for two years at least, and a minimum consumption of 10 cigarettes/ day)

• American Society of Anesthesiologists (ASA) II.

• Normotensive and receiving no medications

• Body mass index of 30 kg/m2

• Mallampati classification I-II

Exclusion Criteria:

1. History of opioid, sedative drugs or medications affecting heart rate or blood pressure.

2. Morbid obesity.

3. Current upper respiratory infection

4. Hypovolemia

5. IHD

6. History of sleep apnea or Difficult Intubation.

7. Emergency procedures.

8. Hepatic or renal impairment.

9. Drug allergy to Dexmeditomidine or fentanyl.