Augmenting Antidepressant Treatment With Interpersonal Psychotherapy for Treating Late-life Depression

• Status: Completed
• Trial end date: 2009-08-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will determine whether adding interpersonal psychotherapy to treatment with the antidepressant escitalopram will be more effective in reducing symptoms of depression than antidepressant medication alone.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Pittsburgh
• Collaborator: National Institute of Mental Health (NIMH)
• Treatments: Citalopram; Dexetimide

Criteria

Inclusion Criteria:

• Diagnosis of unipolar major depression

• Hamilton Rating Scale for Depression (HRSD) (17 item) score of 15 or higher

• Speaks English

• Willing to discontinue other psychotropic medications

• Availability of family member or other caregiver

• Hearing capacity adequate to respond to a raised conversational voice

Exclusion Criteria:

• Lifetime diagnosis of bipolar disorder, schizophrenia, schizoaffective disorder, or any psychotic disorder

• Folstein Mini-Mental Status Exam (MMSE) of 17 or lower

• Suicidal

• History of treatment non-adherence in other Center protocols

• History of documented non-response to citalopram in other Center protocols

• History of non-tolerance to escitalopram therapy