Australasian Resuscitation In Sepsis Evaluation: FLUid or Vasopressors In Emergency Department Sepsis
Status:
Not yet recruiting
Trial end date:
2025-02-01
Target enrollment:
Participant gender:
Summary
This multicentre, randomised controlled trial will enrol 1000 patients presenting with septic
shock to the emergency department (ED) of participating hospitals in Australia and New
Zealand. Participants will receive haemodynamic resuscitation with either a restricted fluids
and early vasopressor regimen or a larger initial IV fluid volume with later introduction of
vasopressors if required. Clinical care including the type of resuscitation fluid and
vasopressor agent, will otherwise be in accordance with accepted standard care and according
to clinician discretion. The study intervention will be delivered for at least 6 hours and up
to 24 hours post-randomisation. Participants will be followed for up to 12 months and
outcomes analysed on an intention-to-treat basis.
Phase:
Phase 3
Details
Lead Sponsor:
Australian and New Zealand Intensive Care Research Centre