Autofluorescence and Indocyanine Green to Avoid Hypocalcemia After Thyroidectomy

• Status: Not yet recruiting
• Trial end date: 2025-05-31
• Target enrollment: 0
• Participant gender: All

Summary

• Hypoparathyroidism (and the resulting hypocalcemia) remains the most common morbidity after a total thyroidectomy.

• The identification and preservation of parathyroid glands during neck surgery has always been challenging but is crucial to avoid postoperative hypocalcemia.

• Recently, the specific autofluorescent characteristics of endogenous fluorophores in the parathyroid tissue have been used to detect and confirm parathyroid glands during thyroid surgery.

• Injecting indocyanine green and using its fluorescent characteristics has the advantage of adding information about the vascular supply of the parathyroid glands.

• This randomized clinical trial aims to investigate whether using autofluorescence and indocyanine green during thyroid surgery can predict or prevent postoperative hypocalcemia.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Onze Lieve Vrouw Hospital
• Treatments: Parathyroid Hormone

Criteria

Inclusion Criteria:

• All adult patients undergoing a total thyroidectomy without previous neck surgery.

Exclusion Criteria:

• Children and teenagers (<18 years old)

• Patients refusing participation or unable/unwilling to sign the informed consent

• Patients with a completion thyroidectomy

• Patients with planned central and lateral neck lymph node dissections (thyroid cancer)

• Patients with previous neck surgery

• Patients with a known allergy/hypersensitivity to indocyanine green