Autologous Adipose-Derived Adult Stromal Vascular Cell Administration for Male Patients With Infertility

• Status: Enrolling by invitation
• Trial end date: 2021-12-30
• Target enrollment: 0
• Participant gender: Male

Summary

Severe Oligospermia (oligozoospermia) refer to semen with a low concentration of sperm and is a common finding in male infertility. Often semen with a decreased sperm concentration may also show significant abnormalities in sperm morphology and motility that affect Male fertility. The purpose of this study is to assess the ability of Autologous Adipose-Derived Adult Stromal Vascular Fraction (SVF) cells to stimulate Sertoli and spermatogonia cells and affect male fertility.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: State-Financed Health Facility "Samara Regional Medical Center Dinasty"
• Treatments: Hormones

Criteria

Inclusion Criteria:

• idiopathic oligozoospermia (spermatozoid number <2x10^6/mL) - 10 patients

• cryptozoospermia/azoospermia - 10 patients

Exclusion Criteria:

• age before 18 or after 60 years old

• heart insufficiency. stroke (during 1 year)

• anemia

• blood disease

• pelvis bone trauma

• chronic diseases in decompensation stage

• skin diseases

• tuberculosis

• hyperprolactinaemia

• hyper or hypothyreosis

• obstructive zoospermia

• sperm stimulating hormone therapy

• Men with previous surgery in testis

• Men with infectious genital diseases and anatomical abnormalities of the genital tract

• Those with major medical problems such as malignancy, hepatitis B . C, etc. HIV

• Chromosomal aberration (e.g. Y microdeletion, trisomy….)