Autologous Cord Blood Cells for Prevention of BPD in Preterm

• Status: Completed
• Trial end date: 2020-01-01
• Target enrollment: 0
• Participant gender: All

Summary

To study the effect of Autologous cord blood cells infusion on prevention of bronchopulmonary dysplasia in very preterm neonates

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: yangjie

Criteria

Inclusion Criteria:

• born in the study hospital;

• singleton birth;

• less than 32 weeks GA

• Without congenital malformations or known chromosomal aberrations;

• Without clinical chorioamnionitis;

• the mother was negative for hepatitis B (HBsAg and/or HBeAg) and C virus (anti-HCV), syphilis, HIV (anti-HIV-1 and -2) and IgM against cytomegalovirus, rubella, toxoplasma and herpes simplex virus;

• consents were obtained from their parents or guardians;

• the umbilical cord blood cells after processing were available.

Exclusion Criteria:

• birth-weight was less than the third percentile for gestational age according to Fenton curve,

• if they had severe perinatal asphyxia (defined as an Apgarscore of 0-3 for more than 5 minutes, a cord blood pH of less than 7.00, or both) and were expected to die shortly after birth.