Autologous Platelet-Rich Plasma (PRP) and Endometrial Thickness

• Status: Unknown status
• Trial end date: 2020-02-27
• Target enrollment: 0
• Participant gender: Female

Summary

The goal of this interventional study is to evaluate the increasing in endometrial thickening after the intrauterine infusion of 0,5-1 ml of autologous Platelet-Rich Plasma (PRP) and the implantation rate in women with thin endometrium undergoing Embryo-transfer, in order to propose a novel therapeutic approach for women with an endometrium < 7 mm unresponsive to standard treatments.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Magna Graecia

Criteria

Inclusion Criteria:

• Endometrial thickness < 7 mm under estrogen replacement therapy or repeated implantation failure

• Age between 18 and 46 years

Exclusion Criteria:

• Age < 18 and > 46 years

• Pregnancy

• Bleeding diathesis

• Previous uterine surgery (miomectomy, cesarean section, etc...)

• Platelet count < 105/μL

• Hemoglobin < 10 g/dL

• Presence of a tumor in the wound bed or metastatic disease

• Current diagnosis of cancer

• Other concomitant active infections