Autologous Tooth Root in Ridge Preservation

• Status: Not yet recruiting
• Trial end date: 2024-07-31
• Target enrollment: 0
• Participant gender: All

Summary

Use your extracted teeth for routine dental care to make an autologous root slice, cover it in your extraction cavity, and give you Vit.D3 locally with the bone material you use. The difference from traditional therapy is autologous Local use of tooth root slices and Vit.D3, bone materials and Vit.D3 are already qualified drugs on the market, but there is no precedent for making slices from autologous tooth roots, which will be a new medical technology that has not been used before test.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Chang Gung Memorial Hospital
• Treatments: Calcitriol

Criteria

Inclusion Criteria:

1. Willing to sign written subject consent to surgery

2. The extraction socket is located in the anterior and posterior areas of the upper and lower jaws.

3. The intraoral extraction socket (bone defect) area will need to receive artificial dental implant treatment in the future.

4. The patient does not have systemic disease.

5. Patients who do not have systemic diseases (such as hypertension, diabetes, heart disease, osteoporosis, bone-related diseases, kidney diseases, thyroid and parathyroid diseases, etc.), and those who need to take preventive antibiotics before tooth extraction/surgery (artificial valve/stent, artificial joint).

Exclusion Criteria:

1. Patients with potentially impaired healing capacity such as cancer, diabetes, bone infection, tuberculosis, hemoglobin abnormal anemia or congenital immunodeficiency conditions, cellulitis, acute periodontal cysts, severe cusp lesions (cyst size) >2mm2) or subjects with dental and jaw lesions.

2. Women who are pregnant or breastfeeding.

3. Exclude heavy smokers or betel nut chewers who smoke more than one pack of cigarettes per day.

4. The bone defect of the extraction socket is severe (especially if the vertical height of the buccal bone defect [corono-apical] exceeds 1/2), other bone regeneration surgery (GBR) is required, otherwise it is impossible to have sufficient alveolar bone height in the future and widths to provide artificial dental implants

5. The root of the tooth has been severely damaged, the root of the active periodontal ligament is lacking, and it is not suitable for autologous root sectioning, and the alveolar bone and apical defect after tooth extraction are severe (the apical lesion with a defect diameter of >3mm in root apex X-ray examination) [apical lesion])