Autopsy Follow-up of Subjects Previously Imaged With Florbetapir F 18 (18F-AV-45) PET in Trial 18F-AV-45-A07
Status:
Completed
Trial end date:
2011-07-01
Target enrollment:
Participant gender:
Summary
This study is designed to test the relationship between measurements of brain amyloid using
florbetapir F 18 PET imaging and true levels of amyloid plaque density as measured by
histopathological assessment. The study will address the following specific aims:
1. To expand the number of subjects included in the A07 (NCT00857415) trial correlation
analysis (measuring the correlation between the global visual rating of brain amyloid
plaque density on an independent blinded read of the florbetapir F 18 PET scan and the
cortical amyloid plaque density at autopsy as assessed by histopathology for subjects in
the autopsy cohort).
2. To determine the sensitivity and specificity of an independent blinded visual read
assessment of the florbetapir F 18 PET scan (Aβ+ or Aβ-) versus the final blinded
neuropathological assessment made at autopsy.