Availability Study of ACTH to Treat Children SRNS/SDNS

• Status: Unknown status
• Trial end date: 2019-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Primary nephrotic syndrome(NS) is a common children renal disease.About 20% primary nephrotic syndrome are steroid-dependent and steroid-resistant.Low serum cortisol is one of the main relapse reasons.Adrenocorticotropic hormone(ACTH)-induced steroidogenesis improve serum cortisol and also direct melanocortin receptors(MCRs) mediated protective effect on kidney cells. To investigate the efficacy and safety of ACTH to treat NS, total 42 children steroid resistant or steroid dependent NS is enrolling in this multicenter, prospective case series of prescription based treatment with ACTH for NS.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
• Treatments: Adrenocorticotropic Hormone; beta-Endorphin; Melanocyte-Stimulating Hormones

Criteria

Inclusion Criteria:

1. age:3-12 years old

2. primary nephrotic syndrome

3. SRNS or SDNS

4. Minor lesion or minimal change disease

5. Signed informed consent

Exclusion Criteria:

1. Second nephrotic syndrome

2. allergic to ACTH

3. Refuse to signed informed consent

4. have had ACTH treatment

5. serious complication