Avelumab With Bempegaldesleukin With or Without Talazoparib or Enzalutamide in Advanced or Metastatic Solid Tumors

• Status: Terminated
• Trial end date: 2020-09-29
• Target enrollment: 0
• Participant gender: All

Summary

Evaluation of the combination of avelumab + bempegaldesleukin (NKTR-214 ) in locally advanced squamous cell carcinoma of the head and neck ( metastatic SCCHN) and avelumab + bempegaldesleukin (NKTR-214) + talazoparib or enzalutamide in metastatic castration resistant prostate cancer (mCRPC).

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Pfizer
• Collaborators: Astellas Pharma Inc; EMD Serono; Nektar Therapeutics
• Treatments: Antibodies, Monoclonal; Avelumab; Talazoparib

Criteria

Inclusion Criteria:

• Participants must be ≥ 18 years old.

• Participants with SCCHN or mCRCP.

• Participants must have histological diagnosis of solid tumors and provide tumor tissue.

• Measurable disease by RECIST v1.1 with at least 1 measurable lesion.

• Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) 0 or 1.

• Adequate bone marrow, renal and liver function

• Highly effective contraceptive use by men with the ability to father a child or women of childbearing potential.

• A WOCBP must have a negative highly sensitive pregnancy test ([urine or serum] as required by local regulations) at C1D1.

• Signed and dated informed consent.

Exclusion Criteria:

• Known prior severe hypersensitivity to investigational products or any component in their formulations, including known severe hypersensitivity reactions to monocolonal antibodies.

• Known history of: immune-mediated colitis, inflammatory bowel disease, pneumonitis, or pulmonary fibrosis.

• Active or prior autoimmune disease that might deteriorate when receiving an immunostimulatory agent.

• Prior organ transplantation including allogenic stem cell transplantation.

• Vaccination within 4 weeks prior to C1D1 and while on trial is prohibited except for administration of inactivated vaccines.

• Known symptomatic brain lesions requiring steroids.

• Known history of testing positive for human immunodeficiency virus (HIV or known acquired immunodeficiency syndrome (AIDS).

• Positive HBV surface antigen or HCV test indicating acute or chronic infection..

• Active infection requiring systemic therapy

• Clinically significant (i.e., active) cardiovascular disease including the following:

documented left ventricular ejection fraction (LVEF) <50% by ECHO/MUGA; cerebral vascular accident/stroke or transient ischemic attack; myocardial infarction; unstable angina; congestive heart failure or serious cardiac arrhythmia (uncontrolled, clinically significant) requiring medication.

• Diagnosis of any other malignancy within 2 years prior to C1D1, except for adequately treated basal cell or squamous cell skin cancer, carcinoma in situ of the breast, bladder or of the cervix and for Combination A only, low-grade (Gleason 6 or below) prostate cancer on surveillance with no plans for treatment intervention (e.g., surgery, radiation, or castration) or adequately treated prostate cancer.

• Current use of immunosuppressive medication at the time of study enrollment.

• Major surgery within 4 weeks prior to study enrollment.

• Conditions that may impair intake or absorption such as inability to swallow capsules or tablets; known malabsorption syndrome; or baseline diarrhea ≤ Grade 1.

• Participation in other studies involving investigational drug(s) within 2 weeks prior to C1D1.