Avelumab With Laser Interstitial Therapy for Recurrent Glioblastoma

• Status: Recruiting
• Trial end date: 2021-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to characterize the safety and tolerability of avelumab in combination with Laser Interstitial Thermal Therapy (LITT) for blood barrier disruption in patients with recurrent glioblastoma.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Icahn School of Medicine at Mount Sinai
• Treatments: Antibodies, Monoclonal; Avelumab

Criteria

Inclusion Criteria:

• Patients must have histologically proven GBM from the initial resection.

• Patients must have a life expectancy > 16 weeks. Patients must have a Karnofsky performance status of ≥ 60 or ECOG 0 - 2

• Patient's requirement for dexamethasone should be ≤ 4mg daily or a stable dose at enrollment.

• Patients must have adequate bone marrow, hepatic and renal function and hemoglobin and the test musts be performed within 14 days prior to study Day 1.

• Highly effective contraception for both male and female subjects if the risk of conception exists.

Exclusion Criteria:

• Known history of autoimmune disorder except diabetes mellitus type 1, vitiligo or hypothyroidism only requiring hormone replacement

• Patients who have received any other therapeutic investigational agent within 30 days of enrollment with the exception of the personalized MTA vaccine (NCT03223103) that can be continued throughout the study.

• Patients who have received any other therapeutic investigational agent within 30 days of enrollment or prior

• Prior placement of intracavitary BCNU-impregnated wafers (Gliadel).

• Prior treatment with checkpoint inhibitors, CTL-4 antibody or other immunotherapy agents

• Presence of any other active malignancy or prior history of malignancy, except for:

basal cell carcinoma of the skin, cervical carcinoma in situ, early stage prostate carcinoma not requiring active treatment.

• Prior organ transplantation, including allogeneic stem cell transplantation

• Significant acute or chronic infections including, among others: HIV, AIDS, HBV

• Pregnancy or lactation

Contact site for full inclusion/exclusion list.