Axillary Lymph Node Preservation Surgery in Reducing Lymphedema in Patients With Breast Cancer

• Status: Terminated
• Trial end date: 2014-05-01
• Target enrollment: 0
• Participant gender: Female

Summary

This pilot phase I and randomized phase II trial studies the best way to perform axillary lymph node preservation surgery and to see how well it works in preventing lymphedema in patients with breast cancer. Lymph node mapping may help in planning surgery to remove breast cancer and affected lymph nodes. It is not yet known whether reverse mapping guided axillary lymph node dissection is more effective than standard axillary lymph node dissection in preventing lymphedema.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: City of Hope Medical Center
• Collaborator: National Cancer Institute (NCI)

Criteria

Inclusion Criteria:

• Patients diagnosed with breast cancer with a planned axillary lymph node dissection planned for breast cancer

Exclusion Criteria:

• Prior lymphedema in either arm

• Prior history of axillary surgery (except for sentinel node biopsies)

• Prior history of chest/axillary radiation

• Need for bilateral axillary node dissection surgery

• Prior neurologic deficits (either motor or sensory) in ipsilateral arm

• Known allergy to vital blue dyes

• No prior diagnosis of inflammatory breast cancer

• Cannot be pregnant or planning to continue breast-feeding immediately after surgery