Azacitidine-CHOP for Patients With Nodal T-cell Lymphoma With T-follicular Helper Phenotype (ACANTUS)

• Status: Not yet recruiting
• Trial end date: 2026-12-31

Summary

Induction treatment (every 3 weeks, total 6 cycles)

• Azacitidine d1-3 (level 1: 50mg/m2, level 2: 75mg/m2, level 3: 100mg/m2, level 4:

125mg/m2)

• Cyclophosphamide 750mg/m2 d1

• Doxorubicin 50 mg/m2 d1

• Vincristine 1.4 mg/m2 (Max: 2 mg) d1

• Prednisolone 100mg PO d1-5 Maintenance treatment (every 4 weeks, total 12 cycles)

• Azacitidine 75mg/m2 d1-5

• Phase: Phase 1/Phase 2

Details

• Lead Sponsor: Won Seog Kim