Azacitidine and Entinostat Before Chemotherapy in Treating Patients With Advanced Non-small Cell Lung Cancer
Status:
Terminated
Trial end date:
2017-04-01
Target enrollment:
Participant gender:
Summary
This randomized phase II trial studies how well azacitidine and entinostat before
chemotherapy works in treating patients with non-small cell lung cancer that has spread to
other places in the body. Drugs used in chemotherapy, such as azacitidine, irinotecan
hydrochloride, gemcitabine hydrochloride, docetaxel, and pemetrexed disodium, work in
different ways to stop the growth of tumor cells, either by killing the cells, by stopping
them from dividing, or by stopping them from spreading. Entinostat may stop the growth of
tumor cells by blocking some of the enzymes needed for cell growth. Giving azacitidine and
entinostat before chemotherapy may work better in treating patients with non-small cell lung
cancer.