Azacitidine and Etanercept in Treating Patients With Myelodysplastic Syndromes

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

This phase I/II trial studies how well giving azacitidine together with etanercept works in treating patients with myelodysplastic syndromes (MDS). Drugs used in chemotherapy, such as azacitidine, works in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Chemoprotective drugs, such as etanercept, may protect normal cells from the side effects of chemotherapy

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fred Hutchinson Cancer Research Center; Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
• Collaborator: National Cancer Institute (NCI)
• Treatments: Azacitidine; Etanercept

Criteria

Inclusion Criteria:

• Int-2 or high risk MDS patients

• Patients with low-risk or int-1 risk MDS by International Prognostic Scoring System (IPSS) criteria with:

• Single or multilineage cytopenia (absolute neutrophil count [ANC] < 1500/μL, hemoglobin [Hgb],10g/dL, or platelet count < 100,000/μL); or

• Transfusion requirement of at least 2 units of packed red blood cells over an 8 week period

• Serum creatinine =< 1.5x ULN (upper limit of normal)

• Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2x ULN

• Performance status =< 2 (Eastern Cooperative Oncology Group [ECOG] scale, 0-5)

Exclusion Criteria:

• Patients who have previously received hematopoietic stem cell transplants, specifically for MDS

• Patients with a diagnosis of acute myeloid leukemia (AML) by World Health Organization (WHO) criteria (i.e >= 20% blasts) at time of enrollment

• Women of child bearing potential who are currently pregnant, lactating or who are not willing to use contraception during the entire duration of the study

• Men who are unwilling to use contraception while receiving 5-aza

• Patients with severe disease other than MDS which is expected to prevent compliance with the present protocol

• Patients with severe infections (pneumonia, septicemia, etc) within the 2 weeks prior to the anticipated start of protocol treatment

• Patients who are currently receiving or within the preceding 2 weeks have received cytotoxic therapy, hemopoietic growth factors, immunomodulatory therapy, or other experimental therapy for the treatment of MDS

• Current evidence of uncontrolled cardiac arrhythmia or congestive heart failure

• Platelet count =< 10,000/mcl

• Absolute neutrophil count =< 250/mcl

• Prior treatment with 5-aza

• Known or suspected hypersensitivity to azacitidine or mannitol