Azacitidine and Homoharringtonine in JMML

• Status: Recruiting
• Trial end date: 2025-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Juvenile myelomonocytic leukemia (JMML) has a poor prognosis in general, with hematopoietic stem cell transplant (HSCT) remaining the standard of care for cure. Azacitidine and homoharringtonine, which exhibited a anticancer mechanism and has been widely used in patients with relapse/refractory acute myeloid leukemia (AML). However, the efficacy of these agents has not been elucidated in children with JMML. The primary objective is to assess the treatment effect on response rate in this subject population.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Air Force Military Medical University, China; Fourth Military Medical University
• Collaborators: Children's Hospital of Hebei Province; Qilu Hospital of Shandong University; Taian City Central Hospital; The Affiliated Hospital of Qingdao University; The Second Hospital of Hebei Medical University
• Treatments: Azacitidine; Homoharringtonine

Criteria

Inclusion Criteria:

• Newly diagnosed JMML, with PB and BM confirming diagnosis prior to informed consent signature, with one of the following:

1. somatic mutation in PTPN11

2. somatic mutation in KRAS

3. somatic mutation in NRAS and HbF % > 5x normal value for age

4. clinical diagnosis of neurofibromatosis Type 1.

Exclusion Criteria:

• 1. Any condition that would prevent the subject from participating in the study.

2. Any condition including the presence of laboratory abnormalities, which places the subject at unacceptable risk if participated in the study.

3. Any condition that confounds the ability to interpret data from the study.