Azathioprine or Mycophenolate Mofetil for Bullous Pemphigoid

• Status: Completed
• Trial end date: 2000-10-01
• Target enrollment: 0
• Participant gender: All

Summary

To investigate the safety and efficacy of oral methylprednisolone combined with azathioprine or mycophenolate mofetil for the treatment of bullous pemphigoid.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital Muenster
• Collaborator: Hoffmann-La Roche
• Treatments: Azathioprine; Mycophenolate mofetil; Mycophenolic Acid

Criteria

Inclusion Criteria:

• clinical lesions suggestive of bullous pemphigoid

• subepidermal blistering upon histological analysis of skin biopsies

• linear deposition of IgG and C3 along the dermo-epidermal junction

• deposition of autoantibodies at the blister roof upon split-skin analysis

Exclusion Criteria:

• treatment with oral or topical corticosteroids, and other immunosuppressive drugs during the previous four weeks