End-of-dose fluctuations e. g. wearing-off are defined as a recurrence of motor and non-motor
Parkinson's Disease (PD) symptoms that precedes a scheduled dose and improves with the next
dose of anti-parkinsonian medication. Azilect® is approved and recommended for therapy of
wearing-off-/End-of-dose fluctuations and improves motor fluctuations significantly in
combination therapy with L-dopa and other parkinsonian medication.