B181 Metobes-III: Weight Loss Maintenance of a New Bioactive Compound (Metobes-Long)

• Status: Completed
• Trial end date: 2005-04-01
• Target enrollment: 0
• Participant gender: Male

Summary

To investigate the 5-hour acute effect on energy expenditure, substrate oxidation and ad libitum food intake after intake of the Metobes-compound (green tea extract, capsaicin, tyrosine, caffeine). Furthermore, to investigate if the effect of the Metobes-compound can be inhibited by blocking the β-adrenergic receptors.

The effect of the Metobes-compound will be investigated by:

1. 5-hour energy expenditure and respiratory quotient (ventilated hood).

2. 5-h change in blood pressure and heart rate

3. 5-h change in sympathetic/parasympathetic ratio.

4. Ad libitum energy intake.

5. Self-reported postprandiel appetite sensations (VAS).

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Copenhagen
• Collaborator: Metabolife

Criteria

Inclusion Criteria:

• 21 healthy Danish normal-weight to obese men (BMI between 20 and 35 kg/m2), 18 to 50 years of age. All subjects must be weight stable (within  3-kg) 2 months prior to study inclusion, non-smoking, non-athletic and have no daily use of medication.

Exclusion Criteria:

• They will be excluded if they do not meet the inclusion criteria and/or the blood pressure is above 165/95 mmHg and/or the ECG is abnormal.