Bacterial Decolonization to Prevent Radiation-induced Oral Mucositis
Status:
Recruiting
Trial end date:
2024-12-31
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine whether bacterial decolonization of the nares prior
to treatment with radiotherapy (RT) for patients with nasopharyngeal carcinoma, can prevent
high-grade radiation-induced oral mucositis (RIOM) and improve quality of life.
This study is being conducted because a randomized clinical trials form Yana Kost et al. have
found bacterial decolonization in the nose prior to initiation of RT was effective for
prevention of acute radiation dermatitis.
Patients in the treatment arm will receive pretreatment with mupirocin ointment to the nares
while patients in the control arm will receive standard of care treatment. Bacterial cultures
will be taken from the nares and mouth, and participants will also complete a quality of life
questionnaire before and after RT.