Balance of Angiotensin II Receptors in Vessel Function After Preeclampsia
Status:
Recruiting
Trial end date:
2024-11-01
Target enrollment:
Participant gender:
Summary
Otherwise healthy women who develop preeclampsia during pregnancy are more likely to develop
and die of cardiovascular disease later in life. The reason why this occurs is unclear but
may be related to impaired endothelial function and dysregulation of the angiotensin system
that occurs during preeclampsia and persists postpartum, despite the remission of clinical
symptoms. The purpose of this investigation is to determine the mechanisms contributing to
this lasting blood vessel damage caused by reduced endothelial function in women who have had
preeclampsia compared to women who had a healthy pregnancy. Identification of these
mechanisms and treatment strategies may lead to better clinical management of cardiovascular
disease risk in these women.
The purpose of this study is to examine differences in the microvascular balance of
angiotensin II receptors women who have had preeclampsia. This will help the investigators
better understand the mechanisms of dysregulated angiotensin II receptors in formerly
preeclamptic women, and how activation or inhibition of these receptors may restore
microvascular function.
In this study, the investigators use the blood vessels in the skin as a representative
vascular bed for examining mechanisms of microvascular dysfunction in humans. Using a
minimally invasive technique (intradermal microdialysis for the local delivery of
pharmaceutical agents) the investigators examine the blood vessels in a dime-sized area of
the skin.
Phase:
Early Phase 1
Details
Lead Sponsor:
Anna Stanhewicz, PhD
Treatments:
Angiotensin II Angiotensinogen Compound 21 Giapreza