Balanced Salt Solution Versus 0.9% Saline Infusion for Prevention of Contrast-induced Acute Kidney Injury (BASIC Trial)
Status:
Completed
Trial end date:
2020-03-01
Target enrollment:
Participant gender:
Summary
As iodinate contrast media (CM) has been widely used in current medical practice, contrast
induced acute kidney injury (CI-AKI) has been an important issue.
Previously, many guidelines suggested prophylaxis protocol using 0.9% saline when CM is
administrated to high risk patients. However, recent studies showed that 0.9% saline might
induce metabolic acidosis due to its supra-physiologic chloride component, and therefore
renal vasoconstriction. In spite of protective effect by volume expansion with saline
infusion, this renal vasoconstriction might have conflicting effect on renal function, as
hypoxic injury is suspected to be the main cause of CI-AKI.
In contrast to 0.9% saline, balanced salt solution has physiologic level of chloride and
neutral pH. Also, recent studies proved preventive effect of balanced salt solution for AKI
in several clinical settings.
Hence, the investigators planned a prospective randomized controlled trial comparing 0.9%
saline and balanced salt solution to prevent CI-AKI.
Phase:
Phase 3
Details
Lead Sponsor:
Seoul National University Hospital
Collaborators:
Bundang CHA Hospital Ewha Womans University Mokdong Hospital Gachon University Gil Medical Center Incheon St.Mary's Hospital Kyungpook National University Kyungpook National University Hospital National Health Insurance Service Ilsan Hospital National Medical Center, Seoul Seoul National University Boramae Hospital Seoul National University Bundang Hospital Seoul St. Mary's Hospital Severance Hospital