Banding Ligation With Carvedilol Versus Carvedilol for the Prevention of First Bleeding

• Status: Terminated
• Trial end date: 2020-06-30
• Target enrollment: 0
• Participant gender: All

Summary

Endoscopic variceal ligation (EVL) and carvedilol have been documented to be effective in prophylaxis of the first bleeding. The efficacy & safety of combining EVL and carvedilol in prophylaxis of the first bleeding is still unknown. This study aims to investigate the value of combination therapy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: E-DA Hospital
• Treatments: Carvedilol

Criteria

Inclusion Criteria:

1. Cirrhosis with esophageal varices are larger than F2.

2. No history of variceal bleeding.

3. In three months have not implemented preventive esophageal variceal ligation. (4)age 20yrs～75yrs.

Exclusion Criteria:

1. Association with HCC or other cancers .

2. Refractory ascites.

3. Jaundice, bilirubin > 5mg/dl.

4. Encephalopathy.

5. Cr.>3mg/dL.

6. A-V,block bradycardia (PR < 60/mim).

7. Hypotension systolic blood pressure<95/mmHg .

8. Refusal to participate.

9. Carvedilol allergy

10. Second degree-third degree Atrio-ventricular block.

11. Bradycardia.

12. WPWsyndrome

13. Hypotension

14. Psychogenic shock.

15. Asthma. All the patients are randomized based on a random number.