Banding Versus Propranolol for Primary Prophylaxis of Variceal Bleeding

• Status: Terminated
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Whether beta-blockers or banding is the best therapy for primary prophylaxis of variceal bleeding is subject to debate. A randomized comparison between the two treatments was performed in candidates for liver transplantation. Patients with Child B and C cirrhosis with high risk varices and no previous variceal bleeding are randomized to propranolol or variceal bleeding. Primary end point is variceal bleeding

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Padova
• Treatments: Propranolol

Criteria

Inclusion Criteria:

• liver cirrhosis

• child pugh>=B7

• studied for transplantation

• age between 18 an 65 ys

• no previous bleeding from varices

• signed informed consent

Exclusion Criteria:

• esophageal varices less than F2 blue

• gastric varices

• previous variceal surgical or radiological or endoscopical treatment

• hepatocarcinoma

• portal vein thrombosis

• severe heart, respiratory or renal failure

• contraindications to betablockers

• treatment with nitrates, calcium antagonist or anti-arhythmic drugs that can not be suspended

• Pregnancy

• neoplasias

• non cooperation